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Filtered Search Results
Medchemexpress LLC SPP-86 | 1357349-91-7 | 99.9% | 277.32 | 100 MG
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SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. It inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, and also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells. This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM.
- Inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling.
- Inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.
- Click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
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Medchemexpress LLC Firmonertinib (mesylate) | 2130958-55-1 | 100.0% | 664.70 | 500 MG
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Firmonertinib mesylate (Alflutinib; Furmonertinib) is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It inhibits EGFR active mutations as well as the T790M acquired resistant mutation, with potential for research into cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations and the T790M acquired resistant mutation
- Potential for research of cancer diseases, particularly advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation
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Medchemexpress LLC SKA-31 | 40172-65-4 | 99.7% | 200.27 | 1 ML
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SKA-31 is a potent potassium channel activator that demonstrates significant activity against KCa3.1, KCa2.2, KCa2.1, and KCa2.3 channels. It potentiates endothelium-derived hyperpolarizing factor response and has been shown to lower blood pressure in studies. This compound is intended for research use only.
- Activates KCa2/3 channels potently and selectively
- Reduces cell viability in HCT-116 and HCT-8 cells
- Triggers apoptosis in HCT-116 cells
- Increases cells in G0/G1 phase
- Potentiates endothelium-derived hyperpolarizing factor response
- Lowers blood pressure in mice
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Medchemexpress LLC 8-Aminoquinoline | 578-66-5 | 144.17 | 100 G
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8-Aminoquinoline is a biochemical reagent suitable for life science related research. It can be used as a biological material or organic compound, and is intended for research use only.
- Biochemical reagent
- Can be used as biological material
- Can be used as organic compound
- Suitable for life science related research
- Functions as an inhibitor
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Medchemexpress LLC NLRP3-IN-11 | 2769040-91-5 | 344.8 | 200 MG
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NLRP3-IN-11 is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) proteins. It demonstrates biological activity for NLRP3 with an IC50 value of less than 0.3 μM. This compound is under research for its potential use in addressing various inflammatory and degenerative diseases.
- Inhibits NLRP3 proteins.
- IC50 value for NLRP3: <0.3 μM.
- IC50 value in human PBMC NLRP3 assay: <0.3 μM.
- Potential research areas include NASH, atherosclerosis, other cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout, and other autoinflammatory diseases.
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Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.9% | 750.70 | 50 MG
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Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, binding to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier. It stimulates [35S]-GTPγS binding at D2 dopamine receptors and acts as a strong inhibitor of brain nitric oxide synthase (neuronal NOS) and a potent inhibitor of CYP3A4.
- Potent dopamine D2/D3 receptor agonist
- Permeable to the blood-brain barrier
- Stimulates [35S]-GTPγS binding at D2 dopamine receptors
- Strong inhibitor of brain nitric oxide synthase (neuronal NOS)
- Potent inhibitor of CYP3A4
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Medchemexpress LLC (S,R,S)-AHPC-amido-C5-acid | 2162120-87-6 | 572.72 | 100 MG
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This product is (S,R,S)-AHPC-amido-C5-acid, a solid laboratory chemical identified as an E3 Ligase Ligand-Linker Conjugate involved in PROTAC design. It is used in the manufacture of various substances and for research purposes.
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
- Stable under recommended storage conditions
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Medchemexpress LLC Amino-PEG12-amine | 361543-12-6 | 99.9% | 588.73 | 1 G
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Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This product is intended for research use only.
- Used in the synthesis of PROTACs
- Molecular weight of 588.73
- Purity of 99.92% by HPLC
- Colorless to off-white solid-liquid mixture
- Store at 4°C, protected from light
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Medchemexpress LLC Nilotinib | 641571-10-0 | 99.9% | 529.52 | 200 MG
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Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity, designed for research use. It exhibits significant inhibitory effects against Bcr-Abl and various other targets, making it suitable for studies on cell proliferation and cytotoxicity.
- Exhibits antiproliferative activity in A549 cells with an IC50 of 6.63 μM.
- Shows antiproliferative activity in BJ cells with an IC50 of 12.8 μM.
- Inhibits various BCR/ABL p210 mutants (GI50 0.004 μM to > 10 μM).
- Induces cytotoxicity against various BaF3 cell lines.
- Used in CCK-8 assays for IC50 assessment in liver cancer cell lines.
- Useful for observing anti-colony formation effects.
- Utilized for immunohistochemistry of primary tumors.
- Investigated for its direct effect on cytotoxic lymphocytes.
- Applied for cell cycle analysis.
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Medchemexpress LLC GW 4064 | 278779-30-9 | 99.8% | 542.84 | 200 MG
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GW 4064 is a potent Farnesoid X Receptor (FXR) agonist with an EC50 of 65 nM.
- Reduces lipid accumulation in cells and represses oleic acid-induced CD36 protein levels, potentially preventing hepatic lipid accumulation.
- Suppresses weight gain and significantly represses diet-induced hepatic steatosis by lowering triglyceride and free fatty acid levels in the liver.
- Markedly reduces lipid transporter CD36 expression without affecting genes directly involved in lipogenesis.
- Attenuates hepatic inflammation.
- Leads to statistically significant reductions in serum activities of ALT, AST, LDH, and ALP, as well as reduced serum bile acid levels, suggesting hepatoprotective benefits.
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Medchemexpress LLC Ataluren | 775304-57-9 | 284.24 | 200 MG
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Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor. It is a new chemical entity that selectively induces ribosomal readthrough of premature but not normal termination codons. This action helps prevent the cell from producing a full-length CFTR protein in vitro and promotes dystrophin production in vivo.
- Selectively induces ribosomal readthrough of premature but not normal termination codons
- Helps prevent the cell from producing a full-length CFTR protein
- Promotes dystrophin production in primary muscle cells
- Rescues striated muscle function in mdx mice
- Well tolerated in animals
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Medchemexpress LLC Sitravatinib | 1123837-84-2 | 99.6% | 629.68 | 200 MG
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Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor that demonstrates potent single-agent antitumor efficacy. It enhances the activity of PD-1 blockade by promoting an antitumor immune microenvironment, making it suitable for various research applications in oncology.
- Orally bioavailable receptor tyrosine kinase (RTK) inhibitor
- Potent single-agent antitumor efficacy
- Enhances PD-1 blockade activity
- Promotes an antitumor immune microenvironment
- Soluble in DMSO for in vitro studies
- Available in solid form for various research needs
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Medchemexpress LLC L-Cystathionine dihydrochloride (Standard) | 61125-50-6 | 99.9% | 295.18 | 10 MG
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L-Cystathionine dihydrochloride (Standard) is an analytical standard that is also a nonprotein thioether and a key amino acid linked to the metabolic state of sulfur-containing amino acids. It offers protection against Homocysteine-induced mitochondria-dependent apoptosis in vascular endothelial cells (HUVECs), indicating an important role in cardiovascular protection. This product is intended for research and analytical applications.
- Analytical standard for L-Cystathionine dihydrochloride.
- Used for research and analytical applications.
- Nonprotein thioether.
- Key amino acid in sulfur-containing amino acid metabolism.
- Protects against Homocysteine-induced mitochondria-dependent apoptosis of HUVECs.
- Plays a significant role in cardiovascular protection.
- Suitable for qualitative, quantitative, and methodological research experiments using techniques like HPLC, GC, and MS.
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Medchemexpress LLC KRAS INHIBITOR-31 100 mg
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KRAS INHIBITOR-31 100MG
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Medchemexpress LLC Lenvatinib | 417716-92-8 | 99.8% | 1 G
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Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor. It inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, demonstrating potent antitumor activities. This compound shows antiproliferative activity and growth inhibition in various cell lines.
- Inhibits VEGFR2, VEGFR3, and VEGFR1
- Inhibits PDGFRα, PDGFRβ, and FGFR1
- Inhibits KIT and RET
- Demonstrates antiproliferative activity
- Available as a solid form
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